On returning to France, he worked with Luc Besson on the production of commercials for Club Internet and L'Oréal as well as on the film Joan of Arc.

[2] In 2008, as part of a wave of French directors employed in Hollywood, he directed his first big-budget American film, The Incredible Hulk.

[3][4] However, in June 2010, Jonathan Liebesman was named as director of the sequel, leaving Leterrier's involvement in future films in doubt.

[6] In March 2015, Deadline Hollywood reported that Leterrier was in talks to direct the shark thriller film In the Deep, for Sony Pictures Entertainment.

[7] However, on 3 June 2015, TheWrap reported that Leterrier had exited the film due to creative differences and the reduction of the previously told budget.