It is operated on a daily basis by TransPennine Express, and is also served by East Midlands Railway and Northern Trains services.

[1] It also served as the terminus of the later East Lincolnshire Railway to Boston, until the closure of the ELR line to passengers in October 1970 following the Beeching cuts.

[citation needed] In 2011 an overbridge was added to the eastern side of the station between platforms 1 and 2, which was opened by then-Great Grimsby MP Austin Mitchell on 19 July that year.

[9] The station is part of the PlusBus scheme which, when purchased along with a train ticket, permits unlimited use of Stagecoach buses in the Grimsby and Cleethorpes urban area.

A test train called at Grimsby Town on 26 June 2023;[19] however, no London service is in the December 2024 timetable,[14] and despite substantial local support, as of October 2024 plans are 'on hold'.