Gross is an unincorporated community in Nassau County, Florida, United States.

It is located on U.S. Route 17 in the north of the county, and is also the northernmost interchange (Exit 380) along Interstate 95 within the State of Florida.

The nearest settlement to Gross is Crandall, Florida, at 3.1 mi (5.0 km) south-southeast.

It became the starting location for the Gross Cutoff, a railroad cutoff from the SAL main line passing through the community, that ran from Gross to Callahan, Florida via a junction with the Callahan Subdivision.

[3] The line was created as a bypass route for passenger trains, such as the Silver Meteor, which often became congested at the larger Union Terminal in Jacksonville.