Founded in 1980 and subsequently expanded, the school had a roll of 943 pupils in November 2019.

The school was opened in 1980 to serve the villages of Bridge of Weir, Houston and their surroundings.

[1] Gryffe High School ranked in eighth place in the 2019 Sunday Times school league tables of state secondaries in Scotland, with 70 per cent of pupils receiving five Higher examination passes.

[3] Since 2010/11, Gryffe High School has consistently received the most placing requests in Renfrewshire from prospective pupils outside of its catchment area.

[6] In 2021, it was ranked as having the second best SQA Higher examination results among state schools in Scotland.