Guérin judicially avoided the dispute between the Ibelins, the regents of Henry I of Cyprus, and Holy Roman Emperor Frederick II.
[5] In 1219, during the Fifth Crusade, a group of Antiochene noblemen had risen up against Raymond-Roupen, then ruler of the Principality of Antioch, who had lost the support of Leo of Armenia.
He authorized Gerald of Lausanne, Patriarch of Jerusalem, to lift the ban if Bohemond agreed to make peace with the Hospitallers.
[8] John of Ibelin, the Old Lord of Beirut and leader of Frederick's opponents in the kingdoms of Jerusalem and Cyprus, tried to convince Bohemond IV to support their cause.
John sent his son, Balian III of Beirut, to Tripoli to negotiate with Bohemond, but the elderly prince remained neutral in the conflict.
[10] In 1233, the Hospitallers under Guérin took a leading part in the successful attack on the principality of Hama, ruled by al-Malek al-Modaffer, emir of Konya (and great-grandson of Saladin's brother Nur ad-Din Shahanshah and son-in-law of the sultan al-Kamil) The motive of this conflict was no more than the refusal of the emir to pay them the tribute due and seems to point to an increasing secularization of the Order's spirit.