Gu-Win is a town in Fayette and Marion counties in the U.S. state of Alabama.

"Gu-Win" and "Guin" are not the same, though the pronunciation is virtually the same, leading to occasional confusion by visitors.

Not wanting to be annexed into Guin or Winfield, it pursued incorporation for itself, and chose the name of the local drive-in theater, "Gu-Win".

U.S. Route 43 passes through the town, leading northwest 3 miles (5 km) to Guin and southeast the same distance to Winfield.

According to the U.S. Census Bureau, the town of Gu-Win has a total area of 1.9 square miles (4.9 km2), all of it recorded as land.

About 11.3% of families and 9.9% of the population were below the poverty line, including 5.3% of those under the age of eighteen and 6.8% of those 65 or over.