Guaduas (Spanish pronunciation: [ˈɡaðwas]) is a municipality and town in Colombia, in the Lower Magdalena Province department of Cundinamarca, about 117 km from Bogotá.

Its main plaza is featured on the Colombian ten-thousand pesos bill, and is one of the seats of the Roman Catholic Diocese of La Dorada–Guaduas The early inhabitants of the "Valley of the Guaduas" were the indigenous Panche people.

It was abandoned after its foundation until December 13, 1610, when Fray Tomas de Morales founded the Franciscan monastery of La Soledad on the same location.

In 1809 Fray Domingo de Petres, a Capuchin architect who also directed the construction of the Cathedral of Bogotá, began building a church in the village.

The first official school was opened in 1833, the town acquired the status of provincial capital in 1857, four years later the local hospital was founded, and in 1871 it was connected to the national telegraph network.