Guanajay is a town and municipality in Artemisa Province in western Cuba, located about 58 km (36 mi) southwest of Havana.

Guanajay is the twin town of Axtla De Terrazas[3] In colonial times it was an acclimatization station for newly arrived troops from Spain, and subsequently became well known as a health resort.

Founded in 1650, it was part of the province of Pinar del Río until 1976.

The country surrounding Guanajay is a fertile sugarcane and tobacco region, and historically it has been an important distribution point in the commerce of the western end of the island.

Guanajay was an ancient pueblo of considerable size and importance as early as the end of the 18th century.