The New Guard version of the Guardians of the Galaxy consisted of Kitty Pryde, Thing, Drax, Venom, Rocket Raccoon, Groot, and later Star-Lord and Gamora During the "Ultimate Invasion" storyline, Maker traveled to Earth-6160 and remade it into his own image.
A 61st Century version of the Guardians of the Galaxy is introduced, consisting of Captain Marvel, Star-Lord, Ultimate Nullifier, and Cosmo Starstalker as well as versions of Starhawk, Yondu, Charlie-27, Aleta Ogord, Martinex, an unidentified Captain Universe, Star Brand, Giraud the Phoenix, Molecule Boy, Gladiator, Major Victory, Fang, Hobgoblin, Magique, Manta, Starbolt, Titan, Gary: Wielder of the Infinity Gauntlet, and other unidentified members.
America Chavez was said to have been a member until she was rendered amnesiac due to being displaced in the time period where she was enslaved by Midas.
Guardians protected millions of worlds, integrating the Shi'ar Imperial Guard to their ranks and ending threats such as the Ultron Dominion and the Celestials, being active for millennia until a temporal crisis is detected by Captain Universe.
Though Captain Marvel is unable to convince America to join them in finding the others since she any memories of being part of the team have been "amputated" as confirmed by Cosmo Starstalker's mind-reading abilities, she gives her a temporal flare should she need them as the Guardians of the Galaxy leave to look for more of their time-displaced members.