Guatimotzin is an opera in one act and nine scenes composed by Aniceto Ortega del Villar to a libretto in Spanish by José Tomás de Cuéllar [es].

A romanticised account of the heroic but doomed defense of Mexico by its last Aztec emperor, Cuauhtémoc, Guatimotzin was one of the earliest Mexican operas to use a native subject and to incorporate indigenous music into its score.

[1] Aniceto Ortega, who was also a prominent physician and surgeon, worked on the composition in his free time between patients and late at night.

[3] According to Robert Stevenson, the latter resembles the third movement of Beethoven's Seventh Symphony rather more than it does indigenous music, but the score would later cause Ortega "to be hailed as a Mexican Glinka".

[6] The sets and costumes were designed by Riccardo Fontana,[7] based on drawings in the Mendoza Codex and advice from prominent historians.