[1] The city belongs to the meso-region of Sul e Sudoeste de Minas and to the micro-region of São Sebastião do Paraíso.
[2] [3] The city center of Guaxupé is located at an elevation of 760 meters a short distance from the state boundary of São Paulo.
Neighboring municipalities are: Pratinha and São Pedro da União (N), Juruaia and Muzambinho (E), Tapiratiba (S), and Guaranésia (W).
Industry is also important with four major factories: Fiação e Tecelagem Guaxupé, belonging to the Kanebo group; PEMG and TECTER (electro-magnetic); Pasqua J.F.
The highest ranking municipality in Minas Gerais in 2000 was Poços de Caldas with 0.841, while the lowest was Setubinha with 0.568.