The Guide River is a river in the Marlborough Region of New Zealand.

It starts near Barefell Pass on the eastern side of the Rachel Range and flows south-east to join the Acheron River, which joins the Waiau Toa / Clarence River and eventually drains into the Pacific Ocean.

[1] The river was named by Sir Frederick Weld and his station manager in 1850,[2] because it guided them from the Barefell Pass to the Acheron River (which they misidentified as the Clarence River).

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