Guide Rock is a village in Webster County, Nebraska, United States.

[4] The town was named after Guide Rock, a hill on the opposite bank of the Republican River.

According to the United States Census Bureau, the village has a total area of 0.50 square miles (1.29 km2), all land.

The racial makeup of the village was 96.0% White, 1.3% Native American, and 2.7% from two or more races.

37.6% of all households were made up of individuals, and 17.4% had someone living alone who was 65 years of age or older.

About 13.2% of families and 17.8% of the population were below the poverty line, including 17.0% of those under the age of eighteen and 3.8% of those 65 or over.