The IUPHAR/BPS Guide to PHARMACOLOGY is an open-access website, acting as a portal to information on the biological targets of licensed drugs and other small molecules.

As with the original IUPHAR-DB, the International Union of Basic and Clinical Pharmacology (IUPHAR) Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR), acts as the scientific advisory and editorial board for the database.

The development and release of the first version of the GtoPdb in 2012 were described in an editorial published in the British Journal of Pharmacology entitled 'Guide to Pharmacology.org- an update'.

The Guide to PHARMACOLOGY is being expanded to include clinical information on targets and ligands, in addition to educational resources.

Between November 2015 and October 2018, the Wellcome Trust supported a project to develop the IUPHAR Guide to IMMUNOPHARMACOLOGY[3] (GtoImmuPdb), based on the GtoPdb schema.

GtoImmuPdb provides a knowledge base that connects immunology with pharmacology, bringing added value and supporting research and development of drugs targeted at modulating immune, inflammatory or infectious components of the disease.