Guillermo Raúl Jenefes (born 7 September 1950, San Salvador de Jujuy) is an Argentine Justicialist Party politician.

He sat in the Argentine Senate representing Jujuy Province in the majority block of the Front for Victory.

Jenefes was educated at schools in Jujuy and at the National University of Córdoba and he graduated as a lawyer specialising in banking law in 1973.

He completed his military service with the 5th Tucumán Infantry Brigade, returning to Jujuy to practise law and teach.

His employee, journalist Juan Carlos Zambrano, was shot and killed days after stating he would reveal the details of corrupt politicians.