Guin /ˈɡjuːɪn/ is a city in Marion County, Alabama, United States.

[2] Guin takes its name from a young country doctor, Dr. Jeremiah ("Jerry") Guin from Tuscaloosa County, who purchased the farm known then as Haley's Trading Post (where is now situate the town of Guin) from a certain John T. Meador in 1870, and who, in turn, had bought the property from a certain Alan Haley, a newcomer to the State, who had built there a country store on the most used road stretching from north to south, in order to accommodate cattle drovers taking their cattle to market in Columbus and Aberdeen, Mississippi.

[4] Jeremiah Guin, while looking for a place to make his home, moved the center of interest about a mile east of Haley's Trading Post (now 12th Street N. and 11 Ave. in present-day Guin).

[5] In the early years of its settlement, a saw mill was built and operated in the town, known originally as Kenney Lumber Company (and later known as Brown Lumber Co.), supplying cut timber to the local community.

On July 13, 2010, the citizens of Guin voted to become the first city in Marion County since Prohibition to allow the sale of alcohol.

According to the U.S. Census Bureau, the city of Guin has a total area of 15.0 square miles (39 km2), all land.

[1] Purgatory Creek runs through the southern part of the city, leading west to Beaver Creek, which continues west to the Buttahatchee River, part of the Tombigbee River watershed.

At the 2000 census there were 2,389 people in 1,027 households, including 666 families, in the city.

At the 2010 census there were 2,376 people in 1,029 households, including 647 families, in the city.

As of the 2020 United States census, there were 2,195 people, 1,038 households, and 667 families residing in the city.

Marion County High School houses grades 7–12.