Guinea failed to register any athletes at the 1972 Summer Olympics in Munich and eventually joined the rest of the African nations to boycott the 1976 Summer Olympics in Montreal.

On 22 July, the eve of the opening ceremony, Guinea announced it would withdraw from the Games due to COVID-19 concerns, but later reversed its decision.

[5] Guinea received an invitation from the Tripartite Commission and the International Judo Federation to send Mamadou Samba Bah in the men's lightweight category (73 kg) to the Olympics.

[6] Guinea received a universality invitation from FINA to send two top-ranked swimmers (one per gender) in their respective individual events to the Olympics, based on the FINA Points System of June 28, 2021.

[7] For the first time since Seoul 1988, Guinea qualified one wrestler for the women's freestyle 57 kg into the Olympic competition, by progressing to the top two finals at the 2021 African & Oceania Qualification Tournament in Hammamet, Tunisia.