The Guisane is a river in the Hautes-Alpes department, Provence-Alpes-Côte d'Azur region of France, a subtributary of the Rhône and tributary of the Durance (in Briançon).

It takes its source in Le Monêtier-les-Bains at the Col du Lautaret.

[1] Its drainage basin is 200 km2 (77 sq mi).

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