The Gulf, Mobile and Ohio (reporting mark GMO) was a Class I railroad in the central United States whose primary routes extended from Mobile, Alabama, and New Orleans, Louisiana, to St. Louis and Kansas City, Missouri, as well as Chicago, Illinois.

From its two parallel lines through eastern Mississippi, the GM&O also served Montgomery and Birmingham, Alabama, as well as Memphis, Tennessee.

In 1996 Illinois Central spun off some of its redundant trackage, including most of the former Gulf, Mobile and Ohio.

On February 11, 1998 the Illinois Central was purchased by the Canadian National Railway (CN) with the integration of operations beginning on July 1, 1999.

[3] The album cover of the 1989 Traveling Wilburys song End of the Line features an upside down photograph of the Ann Rutledge at Lincoln, Illinois in 1953.