Guo is tied with her partner Wu Minxia for winning the most Olympic medals (6) of any female diver[2] and she won the 3m springboard event at five consecutive World Championships.

At the end of the Beijing Games, Guo became the most decorated female Olympic diver,[9] and tied fellow Chinese athlete Fu Mingxia, and Americans Pat McCormick and Greg Louganis with the most gold medals (four).

[11] In synchronized diving, the defending champions Guo, and Wu, who won the event in the 2004 Athens Olympics and three World Championships, had led the entire competition in Beijing, winning the gold medal, with Yuliya Pakhalina and Anastasia Pozdnyakova of Russia, who posted 323.61, winning Silver.

"[14] In 2016, she and her husband Kenneth Fok participated in The Amazing Race China 3, based on a CBS's travel-reality program of the same name.

[15] Guo's social activities after the Athens Olympics were the subject of scrutiny in Mainland Chinese and Hong Kong media news outlets.

[18] During Guo's history in diving, including long-term high-pressure training, damaged her knees, her retina and contributed to her myopia.

Earlier in 2001, she underwent surgery to repair a detached retina in her right eye, but spent only a few months out of the water.