The school is situated between the station Mainz Römisches Theater and the industrial area of the city.
Between 1944 and 47, caused by the war and the destruction of a schoolbuilding after a bombing raid, the school closed for 3 years.
Gustav Stresemann was a Nobel Prize laureate, also famous as head of the foreign office.
1973-89 Theo Hipleh headed Gustav-Stresemann commercial school, followed by Mrs. Nortrud Hummel from 1990 to 1993.
In 2002/03 a basic business training school was added, providing classes to apprentices.
A pupil who has acquired the qualification of the business oriented secondary school specified in foreign languages and has finished this course with a “sufficient” grade or better, can be taken up without attendance of the introductory year 11, immediately to the 12th class (12/1) of the business oriented grammar school.
The general qualification for university entrance examination is accomplished in the second half year of the 13th class.
The pupils start the Qualification Phase 12/1 with their selected subject combinations and have to take it till the last school year 13/2.