In 1909, he began working for an academic journal named Giornale degli economisti e Annali di economia.

His research on money and credit was published as Ricerche sopra la teoria generale della moneta (1932).

[3] After the Second World War, Gustavo Del Vecchio became involved in government decisions, primarily on economic matters.

He served as advisor to Meuccio Ruini, a Minister of Reconstruction of Liberated lands under the Parri cabinet (June–December 1945).

Del Vecchio worked to stabilize the lira and halt inflation, and in August 1947, he became president of the Interministerial Committee on Credit and Savings.

From 1948 to 1950, he held the post of a governor of the International Monetary Fund, and from 1958, he was a member of the National Council for the Economy and Labour.