He founded the short lived Mexican Fascist Party as well as the far-right Confederation of the Middle Class (Spanish: Confederación de la Clase Media or CCM) organization in the 1920s and 1930s respectively.

After graduating, Sáenz de Sicilia studied civil engineering abroad in many different countries.

[10] Sáenz de Sicilia was an assistant to the Secretariat of Foreign Affairs during the Obregón presidency before being let go for "personal differences" in the early 1920s.

[3][4] Sáenz de Sicilia began his silent film career in 1922 co-directing Aguiluchos Mexicanos with Miguel Contreras Torres.

[12][7] The party set out to empower the middle class and counteract Bolshevik and communist influence in Mexico.

[12] In April, Sáenz de Sicilia had told Carleton Beals there were 150,000 members in the fascist party.

[7][14][5] The group was heavily opposed to the government structure set forth by Lázaro Cárdenas as well as the nation-wide labor strikes which were occurring during this period.

[5] In August 1936, Sáenz de Sicilia was arrested along with 8 others for displaying Revolutionary Mexicanist Action propaganda in Mexico City.

[3] Members of the CCM helped establish the Revolutionary Party of National Unification, supporting Juan Andreu Almazán's presidential bid in 1940.