[1] The show debuted on May 31, 2015, with Greg Gutfeld as host and Kat Timpf and Joanne Nosuchinsky as panelists.

[2] After Nosuchinsky left the show in 2016 to pursue an acting career, Tyrus joined as the other regular panelist.

has been taped in front of a live studio audience since early 2016, and features a combination of political satire, comedy, and discussion regarding current events.

[4][5] Following Fox News firing 8pm ET host Tucker Carlson in April 2023, the network saw a significant drop in viewership across all of its shows.

[6] In October 2023, the program entered into another hiatus following the 2023 Israel–Hamas war, similar to when the Russian invasion of Ukraine started.

This was the show's first episode after the attempted assassination of Donald Trump, and its first live broadcast at the 2024 Republican National Convention.

In order to maximize studio audience opportunities, Gutfeld periodically takes the show on tour.

is replaced with an additional hour of Fox News @ Night, as was the case upon the beginning of Russia's invasion of Ukraine on February 23, 2022.

As the extended Ukraine coverage continued for several weeks, rumors surfaced that the show might have been permanently cancelled.

[21][22] The success of the show resulted in Fox News debuting a new comedy program called Fox News Saturday Night in June 2023, which often saw regular panelists Tyrus, Kat Timpf and Tom Shillue serve as interim hosts.

'"[24] When the show debuted in 2015, the cast originally included: the host Greg Gutfeld, panelists Kat Timpf and Joanne Nosuchinsky, producer and writer Gene Nelson, executive producer and announcer Tom O'Connor, and comedian Tom Shillue.

[25][26] When Gutfeld is away, Tom Shillue, Kat Timpf, Tyrus, Dana Perino, Brian Kilmeade and Joe Machi serve as guest hosts.