Guest hosts for the program include Raymond Arroyo, Brian Kilmeade, Jeanine Pirro, Jason Chaffetz, Tammy Bruce, Kayleigh McEnany and Will Cain.

[3] In 2018, Marjory Stoneman Douglas High School student and shooting survivor David Hogg organized an ongoing boycott of the show following a Twitter post in which Ingraham ridiculed him.

[10] The Ingraham Angle's debut program guest was White House Chief of Staff John F. Kelly.

[11] Other guests on The Ingraham Angle have included Univision's Jorge Ramos,[12] former White House Press Secretary Ari Fleischer,[13] attorney and former Harvard Law School professor Alan Dershowitz,[14] former Hillary Clinton State Department advisor and Deputy Secretary of State for Strategic Communications Philippe Reines.

[16] In February 2018, Ingraham was criticized after she publicly said that basketball star LeBron James should not talk about politics and that he should "shut up and dribble.

In October 2020, Ingraham was criticized after she falsely claimed that New Zealand forced arrivals into quarantine "camps" due to COVID-19.

[44] Polling by YouGov BrandIndex in the days following the announcement of the boycott showed that the Fox News brand had sustained significantly more consumer perception damage than any of the advertisers.

[46][47] Ingraham was supported by singer and NRA board member Ted Nugent,[48][49] and talk show host Bill Maher who defended her on the grounds of free speech.

Republican strategist Steve Schmidt speculated why Ingraham's advertisers pulled their support: "...this kid's not scared.

"[50] Fox News co-president Jack Abernethy issued a statement of support for Ingraham: "We cannot and will not allow voices to be censored by agenda-driven intimidation efforts.

During the show's June 18, 2018 broadcast, Ingraham referred to the detention facilities as "essentially summer camps" that "resemble boarding schools."

The report described a Texas detainment facility setup to be like a "dormitory structure" with a cafeteria and rooms that contained four beds in each.