The station lobby was in the middle of the ground floor, and was reached by doors on both the east and west sides of the building.

[1] Passenger service by the Atchison, Topeka and Santa Fe Railway ran until 1971.

Amtrak continued operation of the Texas Chief, which was renamed Lone Star in 1974.

[2] In June 2021, Amtrak released a plan that would add two more Heartland Flyer round trips between Oklahoma City, Oklahoma and Fort Worth, Texas, while extending one round trip to Newton, Kansas.

The extended round trip would bring Amtrak service back to Guthrie.