Once recombined at the Sharp-Henrietta intersection, the Gwynns Falls Trail passes south through Solo Gibbs Park on a unique path until it meets another alignment of Sharp Street.

The trail's mainline, however, turns north onto Warren Street, utilizing bicycle lanes and immediately crossing the tracks of the Baltimore Terminal Subdivision at-grade.

Just past the bridge, it continues north on its own alignment once more, which, after entering the wooded area, widens significantly as it utilizes a section of Ellicott Driveway, a street built in 1917 and since closed to motor vehicles.

Beyond this, the trail turns sharply west, leaving the Ellicott Driveway alignment, which continues north from here and open to motor vehicles.

The Trail bridges a bend in the stream with the Hanover Subdivision passing directly above, and enters Leon Day Park from the south.

The Trail utilizes a loop that completely encircles the park and exits to the north, running parallel to Franklintown Road and passing underneath Hilton Parkway.

It then crosses Morris Road; the Trail turns to follow the path here, climbing up a very steep grade and its surface changing to crushed gravel.

The Gwynns Falls Trail mainline turns south, however, utilizing a section of Wetheredsville Road closed to motor vehicles.

At William Street, the trail moves onto Franklintown Avenue, which utilizes traffic calming measures such as speed bumps as it passes between several homes.

The trail's route follows a steep grade out of the Gywnns Falls valley for roughly 1 mile (1.6 km) before terminating at the section of Hutton Avenue open to motor vehicles, at Carrie Murray Nature Center, connecting it to Windsor Mill Road.

Before Alluvion Street, it turns west onto a unique bike path running against the Middle Branch of the Patapsco River and behind the Greyhound bus terminal.

It comes back to meet the northern terminus of the Baltimore–Washington Parkway's freeway section, splitting from it immediately and running to the east of Annapolis Road.

At Waterview Avenue, the trail re-enters its own bike path just before the intersection, running parallel to and north of it, and crossing the South Baltimore Industrial Track once again.

Additionally, the Middle Branch Trail system is planned to be extended southward through the undeveloped land parallel to the Baltimore Light Rail, toward Anne Arundel County.

However, the Red Line project was cancelled in early 2015 (although it was revived in 2023); Interstate 70 was truncated to the Beltway in 2014, and the stub end is now designated (but not signed) as MD 570.