Gyrovirus

Diseases associated with this genus include: chicken infectious anemia, which is associated with depletion of cortical thymocytes and erythroblastoid cells.

The unique, single protein, trumpet-shaped capsomeres of Gyrovirus are arranged into 12 pentomers yielding a capsid 60 units in size.

VP1 is the 51kd capsid protein; in addition to its structural function, it also contains motifs for rolling circle replication in the C-terminal region.

[6] VP3, also called apoptin, is a 13kd protein that has been shown to independently induce apoptosis in chicken cells.

The circular dsDNA is then used as a template for transcription and for replication via a rolling circle mechanism similar to phiX174.

CAV causes severe anemia, hemorrhaging, and depletion of lymphoid tissue through the destruction of bone marrow erythroblastoid cells.

The genome is 2383 nucleotides long and has three partially overlapping open reading frames encoding the proteins VP1, VP2 and VP3.

Alignment of the nucleotide sequences of the human gyrovirus genome on the basis of a 138-bp segment (nt 1328–1465) of the viral protein 1 gene. The sequences of the isolate from France (FR823283) and of the 6 isolates found in this http://wwwnc.cdc.gov/eid/article/18/6/12-0179_article.htm study are shown. Nucleotide positions are according to isolate FR823283 (1). Hyphens indicate identity with the prototype sequence of isolate FR823283 (1).