The Hôtel Brion, also known as Villa Brion, is a small Art Nouveau hôtel particulier on rue Sleidan in the Neustadt district of Strasbourg, in the French department of the Bas-Rhin.

[1] The hôtel particulier was built by the architect, Auguste Brion (1861–1940), for himself in 1904.

Brion, the scion of a family of artists directly related to the legendary Friederike Brion, was a prolific architect who built four other houses in the same street between 1903 and 1905.

[2] The hôtel is executed in a more exuberant style than most of Brion's other realizations.

For the structure, the architect used timber framing and walls of reinforced concrete the surface of which he then covered with stonemasonry.