[5][6][7][8] This gene is mapped to 22q11.21, centromeric to COMT.

[8] The specific function of this protein has yet to be determined; however, it has been speculated to play a role in transcriptional regulation and/or chromatin and histone metabolism.

[8] Research done by Salomé Adam, Sophie E. Polo, and Geneviève Almouzni indicate that HIRA proteins are involved in restarting transcription after UVC damage.

[9] Function of HIRA gene can be effectively examined by siRNA knockdown based on an independent validation.

[10] It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.