The serotype identifies the more common HLA-B*52 gene products.
HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan.
[6][7] This form of disease is frequently found with Takayasu's arteritis.
[8][9] Takayasu's arteritis appears to have an independent link to B52 associated disease.
[10][11] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.