HMS Deptford was a 50-gun fourth-rate ship of the line of the Royal Navy, launched at Woolwich Dockyard in 1687.

All three ships ordered in 1682/3 (all were launched in 1687) were intended to carry 54 guns each - twenty-two 24-pounders on the lower deck, the same number of demi-culverins (9-pounders) on the upper deck, and ten demi-culverin drakes on the quarterdeck.

She underwent her first rebuild at Woolwich in 1700 (having been ordered "to repair" on 7 June 1699) as a fourth rate of between 46 and 54 guns.

[1] Her second rebuild took place at Portsmouth Dockyard, where she was reconstructed as a 50-gun fourth rate to the 1706 Establishment from 1717 and relaunched on 19 June 1719.

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