At 3 pm on 22 March 1740, the English squadron, composed of the ships Strafford, Norwich, Falmouth and Princess Louisa, the frigate Diamond, the bomb vessels Alderney, Terrible and Cumberland, the fireships Success and Eleanor, and transports Goodly and Pompey, under Vernon's command, began to bombard the Spanish fortress.

Given the overwhelming superiority of the English forces, Captain Don Juan Carlos Gutiérrez Cevallos surrendered the fort on 24 March, after resisting for two days.

In 1743 as part of a squadron commanded by Commodore Charles Knowles participated in the failed attacks to La Guayra and Puerto Cabello.

Enterprise was recommissioned in 1756 at the outbreak of the Seven Years' War, again for service in the West Indies and North America and resumed her duties as Atlantic convoy escort.

In 1762 she was present at the siege and capture of Havana, Cuba, an action involving nearly 60 warships and transports enough for more than 16,000 troops.