HMS Prince Regent was a 120-gun first rate three-decker ship of the line of the Royal Navy, launched on 12 April 1823 at Chatham.

HMS Prince Regent participated in several battles off the coast of Portugal during the Liberal Wars, 1832-1833, when the British intervened on behalf of Dom Pedro to depose his brother Dom Miguel.

She was converted into a screw ship in 1861, and was broken up in 1873.

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