Salisbury was active during the Seven Years' War, serving with George Pocock's fleet, and seeing action in most of his engagements with the Comte d'Aché.

[1] Serving aboard Salisbury as ship's surgeon during this period was Lieutenant James Lind, who carried out several experiments during her sixth patrol in the approaches to demonstrate the effectiveness of citrus fruit as a cure for scurvy.

[3][4] Lind's experiment began on 20 May 1747, when he selected a dozen men with scurvy and tested possible remedies comprising cider, elixir of vitriol, vinegar, sea water, oranges and lemons, and a purgative mixture.

[6][7] Despite Lind's findings, citrus foods were not adopted as a staple in Royal navy shipboard provisions until 1795.

[1] Salisbury was present at the Battle of Cuddalore on 29 April 1758, fighting with George Pocock's fleet against the Comte d'Aché.

Salisbury fought at the Battle of Pondicherry on 10 September 1759, and remained in the East Indies until finally condemned to be broken up as unserviceable at Bombay on 24 April 1761.