[2] Later that year, Seringapatam, now under the command of Charles Sotheby, was again posted to the Mediterranean, this time as part of a small anti-piracy squadron working in the Aegean Islands, off Alexandria, and around the coasts of Syria.

With HMS Cambrian and Cyrene, she shared in the destruction of a Greek pirate ship on 31 January 1825, and another on 9 June of that year, with the result that her men received prize money.

In his Extracts from a Private Journal Kept on Board H. M. S. Seringapatam, in the Pacific (1830), Waldegrave reported on the ship’s visits to Nuku Hiva in the Marquesas, where he was disgusted by the natives' extreme promiscuity, Otaheite in the Society Islands, where he noted that the ruling Queen Pōmare was "sixteen years of age... but has no children", and to Raiatea, Tongatapu, Vavaʻu, and the Friendly Islands.

In June 1854, during the Crimean War, she returned to active service with the Royal Navy under the command of Commodore Henry Dundas Trotter, Commander-in-chief at the Cape of Good Hope.

Her figurehead, showing a turbanned figure riding on a roc, a giant mythical bird, and holding in one hand a red, white, and blue umbrella, survives in the Royal Museums Greenwich.