HNLMS Isaac Sweers was one of four Gerard Callenburgh-class destroyer built for the Royal Netherlands Navy during World War II.

[2] Isaac Sweers was part of the Allied 4th Destroyer Flotilla which torpedoed and sank the Italian cruisers Alberico da Barbiano and Alberto di Giussano on 13 December 1941, at the Battle of Cape Bon.

[3] She riddled Alberto di Giussano with gunfire at short range and launched four torpedoes against the Cigno; all of them missed their target.

Isaac Sweers towed the stricken British destroyer through a field of burning oil and saved her entire crew of 240 sailors.

During Operation Torch, on 11 November 1942, along with HMS Porcupine, Isaac Sweers helped rescue 241 men from the ship Nieuw Zeeland, a Dutch troop transport that had been torpedoed by the German submarine U-380 at 35°57′N 03°58′W / 35.950°N 3.967°W / 35.950; -3.967 - about 80 miles (130 km) east of Gibraltar, in the Mediterranean.