HRH Princess Maha Chakri Sirindhorn Medical Center (Thai: ศูนย์การแพทย์สมเด็จพระเทพรัตนราชสุดาฯ สยามบรมราชกุมารี), abbreviated MSMC Hospital, is a teaching hospital located inside of Srinakharinwirot University Ongkharak Campus, Nakhon Nayok Province, Thailand.

It is one of the two teaching hospitals of Srinakharinwirot University, the other being the Panyananthaphikkhu Chonprathan Medical Center in Nonthaburi Province.

Constructed in 1992 and finished in 1998, the HRH Princess Maha Chakri Sirindhorn Medical Center opened its doors officially in 2000, with HRH Princess Sirindhorn herself conducted the opening ceremony on November 2, 2000.

The hospital's main aim is to serve as the major teaching hospital for both the Faculty of Medicine and other health science-related faculties of Srinakharinwirot University.

The hospital consists of 378 beds, with the total area of 58,595 square meter.