The project to set up the Faculty of Medicine, Srinakharinwirot University was planned since 1980 under the prime ministership of Prem Tinsulanonda and the faculty was officially set up on 13 June 1985, in a partnership with Bangkok Metropolitan Administration.

In 1992, the university saw fit to expand to have a hospital of its own, so the HRH Princess Maha Chakri Sirindhorn Medical Center was constructed at Ongkharak and was completed in 1999.

Currently, clinical year students rotate around the HRH Princess Maha Chakri Sirindhorn Medical Center and Panyananthaphikkhu Chonprathan Medical Center as main teaching hospitals, as well as affiliated hospitals.

[3] A total of 200 medical students are annually accepted at the Faculty of Medicine, Srinakharinwirot University in the 2018 academic year.

180 students are accepted via the Consortium of Thai Medical Schools Examination (กสพท) and study the whole MD course in Thailand, while 20 students are accepted into the Joint Medical Programme through BMAT Test and study half of the time in the United Kingdom and the other half in Thailand.