9956195646ENSG00000122254ENSMUSG00000046321Q9Y278Q673U1NM_006043NM_001081327NM_177575NP_006034NP_001074796Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

[5][6] Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities.

It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity.

This gene is expressed predominantly in brain and may play a role in the nervous system.

[7] Functional analysis revealed that upregulation of HS3ST2 in human breast cancer cells resulted in altered invasiveness, which was due to changes in Mitogen-activated protein kinase signaling and matrix metalloproteinase expression.