728655n/aENSG00000251164ENSG00000276019n/anan/an/an/an/an/aIn molecular biology, Highly Up-regulated in Liver Cancer (non-protein coding), also known as HULC, is a long non-coding RNA.
[2][3] It may have a role in the post-transcriptional regulation of gene expression.
[2] It downregulates the expression of several microRNAs, including miR-372.
miR-372 represses translation of the kinase PRKACB, so downregulation of miR-372 leads to increased levels of PRKACB.
PRKACB activates CREB by phosphorylation, therefore leading to increased expression of HULC.