Directed by Wenn V. Deramas, it stars Judy Ann Santos, Gladys Reyes, Derek Ramsay, Joem Bascon, Will Devaughn, Rio Locsin, Tetchie Agbayani, John Arcilla, and Gina Alajar.

It aired on the network's Primetime Bida line up and worldwide on TFC from February 1 to May 14, 2010 replacing Boys Over Flowers: One More Time.

The main storyline centered on Jane Alcantara-Briones, a strong-willed nurse who underwent family, career, and love challenges in both the Philippines and the United States.

This series will also bring back the arch-rivalry of Judy Ann Santos and Gladys Reyes from the big hit teleserye, Mara Clara.

Luckily, Nurse Rose Caparas (Gina Alajar) and her young daughter Jane aka Jing-Jing, are there to aid those who are hurt from the terrible wreck.

Sam instantly falls for Jane and apparently so does Nathan; the three of them form a bond and promise to be friends forever.

One fateful day, Nathan sees his father Manuel kissing Rose and catches this moment on film.

As an act of embracing his new future and letting go of the tragedy of his past, Sam changes his name to David Briones.

While under the care of her cruel aunt, Jane befriends Nonoy, a young boy who hopes to reconcile with his long lost mother.

The all-grown-up Jane (Judy Ann Santos) finishes high school, and luckily she gets a college scholarship for the course she has always dreamed of—nursing.

However, all of this is challenged when she meets David Briones (Derek Ramsay) - the arrogant and womanizing owner of the hospital Jane works for.

Meanwhile, Raon (Joem Bascon), finds Rose and does everything in his power to try to restore her back to her normal state.

In his attempt to heal Rose, Raon runs into his father Manuel at a community hospital but does not reveal his true identity to the doctor.

David, now hurting from what he discovered, tries to find a way to tell Jane his secret: That he is in fact Sam and the one responsible for her mother's accident.

Production started January 2008 under the direction of Andoy Ranay, Mark Meily, and John Lazatin.

In November 2009, ABS-CBN held its trade show for its upcoming programs for 2010 where it was announced that Habang May Buhay will begin airing during the first quarter of 2010.