Haimabati Ghosh was born in the Khulna district, Bengal Presidency (now Bangladesh).

After her second marriage, she attended the Campbell Medical College in Calcutta,[3][4] and graduated at the top of her class in 1894.

[5] Sen was a physician at the Lady Dufferin Women's Hospital in Hooghly from 1894 to 1910,[3][6] and had a private practice in Chinsurah, until her death in the early 1930s.

[5] She wrote a "valuable"[2] memoir in the 1920s, detailing her own struggles and her concerns for all young women: "Do I have to suffer all this simply because I am a woman?

Without the support of her husband, parents, brothers, or in-laws, she sought assistance at a widows' house in Benares, and joined the Brahmo Samaj community.