The line is single here with a passing loop approximately 398 metres (435 yd) east of Hairmyres Station, which extends for approximately 584 metres (639 yd) to Kirktonholme Road East Kilbride.

Although the line was always single between Busby and East Kilbride, sidings existed to serve the former Radio Times factory in the College Milton Industrial Estate adjacent to the station.

The Hairmyres Hospital and Department for International Development's office are located nearby.

In the 2020s, plans were advanced to rebuild the station 600m to the west of its original location.

The station has a daily half-hourly service, served exclusively by British Rail Class 156 DMU's, in each direction northbound to Glasgow Central and southbound to East Kilbride.