The daughter of filmmakers Charles Shyer and Nancy Meyers, she had small roles in several of her parents' films.
Meyers-Shyer was born in Los Angeles, California, the daughter of filmmakers Nancy Meyers and Charles Shyer.
In 2012, it was announced that Meyers-Shyer's script The Chelsea would be made into a film starring Felicity Jones and directed by Nancy Meyers.
The film starred Reese Witherspoon as a 40-year-old single mother who allows three young aspiring filmmakers (Pico Alexander, Nat Wolff, and Jon Rudnitsky) to live with her in her Los Angeles home.
[6][7] On October 8, 2024, her second film as writer and director, Goodrich, starring Michael Keaton, was released in theaters by Ketchup Entertainment.