The former Bergedorfer Bahnhof was extended for the needs of the Berlin-Hamburg railway using red brick with plastered cornices and provided with a 148-meter-long and 23.5 m-high wooden train shed with four tracks.
The station building was divided into departure and arrival areas with a baggage check-in and check-out and waiting rooms of different classes.
The commissioning took place on 15 December 1846, but the renovation and construction of the 173 m-long building complex, the freight tracks and the roundhouse were not completed until 1857.
Present-day Hamburg Hauptbahnhof lies a few hundred meters to the north, the Oberhafen (upper port) to the south.
As part of the preparations for the construction of the Hamburg Hauptbahnhof, the Berliner Bahnhof was closed on 1 May 1903 and a temporary station was built on Lippeltstraße.