The Hamilton-Holly House is a Federal style townhouse at 4 St. Mark's Place in the East Village neighborhood of Manhattan in New York City.

The house is built of brick in a Flemish bond pattern with white marble at the basement level up till the beginning of the first floor, it has a high front stoop to the main entrance on the left which is characterized by the Baroque style Gibbs surround entrance with triple keystone and vermiculated blocks and long parlor-floor windows, molded pediment lintels and a peaked roof with two dormer windows.

[1] An auditorium in the basement level of the building became, in the 1950s and 1960s, the home of the Tempo Playhouse, which staged the American premieres of works by Jean Genet and Eugène Ionesco.

[2] For over forty years, from 1975 to February 2016, the first floor and basement were occupied by Trash and Vaudeville, a punk fashion store.

[5] Portions of a renovation plan were approved by the Landmarks Preservation Commission in November 2016, including approval for restoration of the façade, reconstruction of the grand curved balcony at the first floor, a new entryway, and rebuilding the interior space to provide additional residential units.