Henry Washington Wyse (March 1, 1917 – October 22, 2000) was an American professional baseball pitcher.

Between 1942 and 1951, Wyse played in Major League Baseball for the Chicago Cubs (1942–47), Philadelphia Athletics (1950–51) and Washington Senators (1951).

A native of Lunsford, Craighead County, Arkansas, he was listed as 5 feet 11 inches (1.80 m) tall and 185 pounds (84 kg) and he batted and threw right-handed.

In his eight-season MLB career, Wyse posted a 79–70 won–lost record with a 3.52 ERA, 362 strikeouts, 11 shutouts, eight saves, and 12572⁄3 innings in 251 games pitched, 159 as a starter.

His most productive season came in 1945, when he helped the Cubs win the National League pennant after going 22–10 with a 2.68 ERA.