Earnest Preston "Tiny" Osborne (April 9, 1893 – January 5, 1969) was an American pitcher in Major League Baseball who played from 1922 to 1925 for the Chicago Cubs and Brooklyn Robins.

His nickname was ironic: Osborne was listed as 6 feet 4 inches (1.93 m) tall and 215 pounds (98 kg).

The native of Porterdale, Georgia, batted left-handed and threw right-handed.

In 142 big-league games pitched, including 74 starting assignments, and 646 innings, Osborne allowed 693 hits and 315 bases on balls.

This biographical article relating to an American baseball pitcher born in the 1890s is a stub.