On March 26, 1841, she married Thomas Ellwood Longshore of Philadelphia,[3] who was supportive of her medical career.

[1][2] As Philadelphia-based Female Medical College had established a faculty-exchange system with the New England Female Medical College in Boston, Longshore found a position in Boston demonstrating anatomy from February to June 1852.

During the course of her career, Longshore wrote and gave public talks (titled "Lectures to Women")[3] and, according to her husband, saw approximately 40 patients a day at her clinical practice.

[6] At first she found difficulty after opening her practice; other doctors mocked her and pharmacists refused to fulfill her prescriptions - a hardship that she countered by carrying her own medications, thus "pleasing her patients.

"[4][7] She eventually stopped teaching and lecturing in favor of focusing on her practice, where she worked for a further 40 years and retired with a "modest fortune.